Approximately 35-40k people die in car accidents in the US. Last year it was about 37k. On a per VMT rate, it's a pretty flat rate over the past decade.
70k died of drug overdose last year alone, up from 63k in 2016 which in turn is up from 52k in 2015. Drug OD deaths have more than tripled since 1999 and mostly due to opioids